Hi Kim,
We cannot designate a customer as 'non-taxable'. If you are using the shipping method to determine the tax schedule ID (this is the default behavior) it goes by the delivery type. What I have done is to create a Schedule ID called EXEMPT PICKUP. And then mark it as a Delivery shipping type. That way, the system will always be looking at the customer's tax schedule, but I can still have my invoice marked with a Pick Up delivery method.
Kind regards,
Leslie